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Pernicious anemia

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Nevertheless, advances in neuroimaging, biomarker analysis, and longitudinal cohort studies have enabled researchers to corroborate key mechanistic pathways in humans, particularly those involving neurotrophic deficits, hippocampal atrophy, and neurotransmitter dysregulation

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Neurology (1998) 10

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The off-period prevents receptor downregulation and maintains responsiveness

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